What is the downside of rhodiola?

Author: Jesse

Apr. 29, 2024

Rhodiola | NCCIH

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RHODIOLA - Uses, Side Effects, and More

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Bawa, A. S. and Khanum, F. Anti-inflammatory activity of Rhodiola rosea--"a second-generation adaptogen". Phytother.Res 2009;23(8):1099-1102. View abstract.

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Calcabrini, C., De, Bellis R., Mancini, U., Cucchiarini, L., Potenza, L., De, Sanctis R., Patrone, V., Scesa, C., and Dacha, M. Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes. Arch Dermatol Res 2010;302(3):191-200. View abstract.

Challem, J. Medical journal watch:context and applications. Rhodiola may help treat anxiety. Alternative & Complementary Therapies 2008;14(4):220-221.

Chen, Q. G., Zeng, Y. S., Qu, Z. Q., Tang, J. Y., Qin, Y. J., Chung, P., Wong, R., and Hagg, U. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. 2009;16(9):830-838. View abstract.

Chen, T. S., Liou, S. Y., and Chang, Y. L. Antioxidant evaluation of three adaptogen extracts. Am J Chin Med 2008;36(6):1209-1217. View abstract.

Chen, Z. G., Lu, Y., Wang, Z. T., Tao, X. Y., and Wei, D. Z. Protective effects of salidroside on hypoxia/reoxygenation injury by sodium hydrosulfite in PC12 cells. Pharmaceutical Biology (Netherlands) 2007;45:604-612.

De Sanctis, R., De Bellis, R., Scesa, C., Mancini, U., Cucchiarini, L., and Dacha, M. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors 2004;20(3):147-159. View abstract.

Dement'eva, L. A. and Iaremenko, K. V. [Effect of a Rhodiola extract on the tumor process in an experiment]. Vopr.Onkol 1987;33(7):57-60. View abstract.

Duhan, O. M., Baryliak, I. R., Nester, T. I., Dvornyk, A. S., and Kunakh, V. A. [The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test]. Tsitol.Genet. 1999;33(6):19-25. View abstract.

Earnest, C. P., Morss, G. M., Wyatt, F., Jordan, A. N., Colson, S., Church, T. S., Fitzgerald, Y., Autrey, L., Jurca, R., and Lucia, A. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. 2004;36(3):504-509. View abstract.

Evdokimov, V. G. [Effect of cryopowder Rhodiola rosae L. on cardiorespiratory parameters and physical performance of humans]. Aviakosm.Ekolog.Med 2009;43(6):52-56. View abstract.

Evstatieva, L., Todorova, M., Antonova, D., and Staneva, J. Chemical composition of the essential oils of Rhodiola rosea L. of three different origins. Pharmacogn.Mag. 2010;6(24):256-258. View abstract.

Fintelmann, V. and Gruenwald, J. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv.Ther 2007;24(4):929-939. View abstract.

Gupta, V., Lahiri, S. S., Sultana, S., Tulsawani, R. K., and Kumar, R. Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C-H-R) exposure and post-stress recovery. Food Chem.Toxicol. 2010;48(4):1019-1025. View abstract.

Hu, X., Lin, S., Yu, D., Qiu, S., Zhang, X., and Mei, R. A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol. 2010;26(6):499-507. View abstract.

Hu, X., Zhang, X., Qiu, S., Yu, D., and Lin, S. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem.Biophys.Res Commun. 7-16-2010;398(1):62-67. View abstract.

Huang, S. C., Lee, F. T., Kuo, T. Y., Yang, J. H., and Chien, C. T. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol 10-31-2009;52(5):316-324. View abstract.

Hung, S. K., Perry, R., and Ernst, E. The effectiveness and efficacy of Rhodiola rosea L.: A systematic review of randomized clinical trials. Phytomedicine. 2-15-2011;18(4):235-244. View abstract.

Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. View abstract.

Ip, S. P., Che, C. T., and Leung, P. S. Association of free radicals and the tissue renin-angiotensin system: prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury. JOP. 2001;2(1):16-25. View abstract.

Jafari, M., Felgner, J. S., Bussel, I. I., Hutchili, T., Khodayari, B., Rose, M. R., Vince-Cruz, C., and Mueller, L. D. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation.Res 2007;10(4):587-602. View abstract.

Jeong, H. J., Ryu, Y. B., Park, S. J., Kim, J. H., Kwon, H. J., Kim, J. H., Park, K. H., Rho, M. C., and Lee, W. S. Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg.Med Chem. 10-1-2009;17(19):6816-6823. View abstract.

Kiefer, D. Rhodiola rosea for General Anxiety Disorder. Alternative Medicine Alert 2008;11(6):61-65.

Kobayashi, K., Yamada, K., Murata, T., Hasegawa, T., Takano, F., Koga, K., Fushiya, S., Batkhuu, J., and Yoshizaki, F. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med 2008;74(14):1716-1719. View abstract.

Krasik ED, Morozova ES Petrova KP Ragulina GA Shemetova LA Shuvaev VP. Therapy of asthenic conditions: clinical perspectives of application of Rhodiola rosea extract (golden root). Proceedings Modern problems in psycho-pharmacology.Kemerovo-city, Russia: Siberian Branch of Russian Academy of Sciences 1970;298-330.

Lazarova, M. B., Petkov, V. D., Markovska, V. L., Petkov, V. V., and Mosharrof, A. Effects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find.Exp.Clin.Pharmacol. 1986;8(9):547-552. View abstract.

Lee, F. T., Kuo, T. Y., Liou, S. Y., and Chien, C. T. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med 2009;37(3):557-572. View abstract.

Li, H. B., Ge, Y. K., Zheng, X. X., and Zhang, L. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 7-7-2008;588(2-3):165-169. View abstract.

Li, X., Ye, X., Li, X., Sun, X., Liang, Q., Tao, L., Kang, X., and Chen, J. Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res 1-15-2011; View abstract.

Mao, G. X., Wang, Y., Qiu, Q., Deng, H. B., Yuan, L. G., Li, R. G., Song, D. Q., Li, Y. Y., Li, D. D., and Wang, Z. Salidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative status. Mech.Ageing Dev 2010;131(11-12):723-731. View abstract.

Mao, Y., Zhang, X., Zhang, X., and Lu, G. Development of an HPLC method for the determination of salidroside in beagle dog plasma after administration of salidroside injection: application to a pharmacokinetics study. J Sep.Sci 2007;30(18):3218-3222. View abstract.

Maslov, L. N., Lishmanov, Y. B., Arbuzov, A. G., Krylatov, A. V., Budankova, E. V., Konkovskaya, Y. N., Burkova, V. N., and Severova, E. A. Antiarrhythmic activity of phytoadaptogens in short-term ischemia-reperfusion of the heart and postinfarction cardiosclerosis. Bull Exp.Biol Med 2009;147(3):331-334. View abstract.

Narimanian, M., Badalyan, M., Panosyan, V., Gabrielyan, E., Panossian, A., Wikman, G., and Wagner, H. Impact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Phytomedicine 2005;12(10):723-729. View abstract.

Noreen, E., Buckley, J., and Lewis, S. The effects of an acute dose of Rhodiola rosea on exercise performance and cognitive function. Journal of the International Society of Sports Nutrition 2009;6(Suppl 1):14p.

Panossian, A., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats. Phytother.Res 2009;23(3):351-357. View abstract.

Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. View abstract.

Panossian, A., Wikman, G., and Sarris, J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493. View abstract.

Provino, R. The role of adaptogens in stress management. Australian Journal of Medical Herbalism 2010;22(2):41-49.

Qian, E. W., Ge, D. T., and Kong, S. K. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. 1-27-2011;133(2):308-314. View abstract.

Qu, Z. Q., Zhou, Y., Zeng, Y. S., Li, Y., and Chung, P. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects. Biomed.Environ Sci 2009;22(4):318-326. View abstract.

Rohloff, J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry 2002;59(6):655-661. View abstract.

Schriner, S. E., Abrahamyan, A., Avanessian, A., Bussel, I., Maler, S., Gazarian, M., Holmbeck, M. A., and Jafari, M. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic.Res 2009;43(9):836-843. View abstract.

Schriner, S. E., Avanesian, A., Liu, Y., Luesch, H., and Jafari, M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic.Biol Med 9-1-2009;47(5):577-584. View abstract.

Schulzz, V. Rhodiola rosea radix extract for the treatment of mild to moderate depression? Results of a placebo-controlled clinical study. KIM - Komplementare und Integrative Medizin, Artztezeitschrift fur Naturheilverfahren 2009;3(2):36-41.

Skarpanska-Stejnborn, A., Pilaczynska-Szczesniak, L., Basta, P., and Deskur-Smielecka, E. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc.Metab 2009;19(2):186-199. View abstract.

Ssaratikov, A. S., Krasnov, E. A., Chnikina, L. A., Duvidson, L. M., Sotova, M. I., Marina, T. F., Nechoda, M. F., Axenova, R. A., and Tscherdinzeff, S. G. [Rhodiolosid, a new glycoside from Rhodiola rosea and its pharmacological properties]. Pharmazie 1968;23(7):392-395. View abstract.

Tan, C. B., Gao, M., Xu, W. R., Yang, X. Y., Zhu, X. M., and Du, G. H. Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride. Biol Pharm Bull 2009;32(8):1359-1363. View abstract.

Udintsev, S. N. and Schakhov, V. P. Decrease of cyclophosphamide haematotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur.J Cancer 1991;27(9):1182. View abstract.

Udintsev, S. N. and Shakhov, V. P. The role of humoral factors of regenerating liver in the development of experimental tumors and the effect of Rhodiola rosea extract on this process. Neoplasma 1991;38(3):323-331. View abstract.

van, Diermen D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., and Hostettmann, K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 3-18-2009;122(2):397-401. View abstract.

Walker, T., Altobelli, S., Caprihan, A., and Robergs, R. Muscle phosphate kinetics following Rhodiola Rosea ingestion. Journal of Exercise Physiology Online 2006;9(2):11.

Wang, H., Ding, Y., Zhou, J., Sun, X., and Wang, S. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Phytomedicine. 2009;16(2-3):146-155. View abstract.

Wiegant, F. A., Surinova, S., Ytsma, E., Langelaar-Makkinje, M., Wikman, G., and Post, J. A. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. 2009;10(1):27-42. View abstract.

Wu, T., Zhou, H., Jin, Z., Bi, S., Yang, X., Yi, D., and Liu, W. Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol 6-24-2009;613(1-3):93-99. View abstract.

Wu, Y. L., Piao, D. M., Han, X. H., and Nan, J. X. Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol Pharm Bull 2008;31(8):1523-1529. View abstract.

Xu, K. J., Zhang, S. F., and Li, Q. X. [Preventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(9):648-650. View abstract.

Yu, S., Liu, L., Wen, T., Liu, Y., Wang, D., He, Y., Liang, Y., Liu, X., Xie, L., Wang, G., and Wei, W. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 1-1-2008;861(1):10-15. View abstract.

Zaiteva, S. I., Matveeva, S. L., Gerasimova, T. G., Pashkov, Y. N., Butov, D. A., Pylypchuck, V. S., Frolov, V. M., and Kutsyna, G. A. Efficacy and safety of phytoconcentrate Dzherelo (Immunoxel) in treatment of patients with multi-drug resistant TB (MDR-TB) in comparison to standartd chemotherapy. Research Journal of Medical Sciences 2009;3(2):36-41.

Zhang, L., Yu, H., Zhao, X., Lin, X., Tan, C., Cao, G., and Wang, Z. Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem.Int 2010;57(5):547-555. View abstract.

Zhang, Z. H., Feng, S. H., Hu, G. D., Cao, Z. K., and Wang, L. Y. [Effect of Rhodiola kirilowii (Regel.) Maxim on preventing high altitude reactions. A comparison of cardiopulmonary function in villagers at various altitudes]. Zhongguo Zhong.Yao Za Zhi. 1989;14(11):687-90, 704. View abstract.

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Karosanidze I, Kiladze U, Kirtadze N, et al. Efficacy of adaptogens in patients with long COVID-19: a randomized, quadruple-blind, placebo-controlled trial. Pharmaceuticals (Basel) 2022;15(3):345. View abstract.

Kasper S, Deniel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. 2017 Mar 22;13:889-98. View abstract.

Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev 2001;6:293-302. View abstract.

Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19. View abstract.

Kormosh, N., Laktionov, K., and Antoshechkina, M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother Res 2006;20(5):424-425. View abstract.

Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32. View abstract.

Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. View abstract.

Li T, Xu L, Sun C. Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinensis. Phytomedicine 2007;14:601-4. View abstract.

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Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31. View abstract.

Noah L, Morel V, Bertin C, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022 Apr 29;14(9):1863. View abstract.

Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res 2013;27(3):839-47. View abstract.

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Pkhaladze L, Davidova N, Khomasuridze A, Shengelia R, Panossian AG. Actaea racemosa L. is more effective in combination with Rhodiola rosea L. for relief of menopausal symptoms: a randomized, double-blind, placebo-controlled study. Pharmaceuticals (Basel). 2020;13(5):102. View abstract.

Roumanille R, Vernus B, Brioche T, et al. Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats. J Int Soc Sports Nutr 2020;17(1):58. View abstract.

Ryan ED, Gerstner GR, Mota JA, et al. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. J Diet Suppl 2021;18(5):507-516. View abstract.

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Shanely RA, Nieman DC, Zwetsloot KA, et al. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain Behav Immun 2014;39:204-10. View abstract.

Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. View abstract.

Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11. View abstract.

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Spasov AA, Wikman GK, Mandrikov VB, et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000;7:85-89. View abstract.

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Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. View abstract.

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Wing SL, Askew EW, Luetkemeier MJ, et al. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med 2003;14:9-16. View abstract.

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Zhang ZJ, Tong Y, Zou J, et al. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin J Integr Med 2009;15:177-83. View abstract.

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